The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor
and Contributes to the Development of Experimental Dermal Fibrosis

Fibrosis arises from excessive deposition of extracellular matrix components and results in scarring of various tissues. It is a hallmark of systemic sclerosis (SSc), which is a prototypical fibrotic disease affecting both the skin and many internal organs such as the lungs and gastrointestinal tract.