TGFβ receptor gene variants in systemic sclerosis-related pulmonary arterial hypertension: results from a multicentre EUSTAR study of European Caucasian patients

TGFβ receptor gene variants in systemic sclerosis-related pulmonary arterial hypertension: results from a multicentre EUSTAR study of European Caucasian patients

Systemic sclerosis (SSc) is characterised by major vascular involvement. Pulmonary arterial hypertension (PAH) is currently an important challenge in SSc and given the severity of this condition and the poor understanding of its risk factors and pathogenesis, there is an urgent need to identify novel risk factors for the development of SSc–PAH.