Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis

Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis

Systemic sclerosis (SSc, scleroderma) is a connective tissue disease of unknown etiology that affects particularly the skin. Early stages of SSc are characterized by vascular changes and inflammatory infiltrates in the lesional skin.

RMDs are highly prevalent and significantly affect activity limitations and participation restrictions. More effort is needed to improve care and research in this field.