Dr Emmanuel GIBON

Praticien Hospitalier

Service : Chirurgie orthopédique

Spécialités : prothèses de hanche et de genou

Sur-spécialité(s) : reprise de prothèses de hanche et genou

Téléphone : +33 (0)1 58 41 31 04

Fax : +33 (0)1 58 41 30 97

Email : annick.helan@aphp.fr

Intérêts :

recherche clinique et fondamentale, application de la science fondamentale à des problèmes pratiques, biomécanique, arthrose, ingéniérie tissulaire

Activité de recherche :

effet des particules de prothèse articulaire sur le corps humain, prothèses de hanche et de genou, macrophages, cellules souches, inflammation

Diplômes :

– Doctorat de médecine

– Diplôme universitaire de réparation juridique du dommage corporel

– Diplôme universitaire d’anatomie fonctionnelle de l’appareil locomoteur

– Master 2 de sciences chirurgicales

– Diplôme d’études spécialisées complémentaires de chirurgie orthopédique et traumatologique

– Diplôme d’études spécialisées en chirurgie générale

Activité hospitalière :

chirurgie, consultation, enseignement

Publications :

Lin W, Xu L, Zwingenberger S, Gibon E, Goodman SB, Li G. Mesenchymal stem cells homing to improve bone healing. Journal of Orthopaedic Translation. 2017;9:19-27.

Gibon E, Goodman SB. Aging and Cell Therapy for the Treatment of Osteonecrosis of the Femoral Head. J Hip Surg. 2017;01:003-06

Lu LY, Loi F, Nathan K, Lin T-H, Pajarinen J, Gibon E, et al. Pro-inflammatory M1 macrophages promote osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway. Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society. 2017.

Nabeshima A, Pajarinen J, Lin T-H, Jiang X, Gibon E, Córdova LA, Loi F, Lu L, Jämsen E, Egashira K, Yang F, Yao Z, Goodman SB. Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model. Biomaterials 2017;117:1-9.

Gibon E, Amanatullah FA, Loi F, Pajarinen J, Nabeshima A, Yao Z, Hamadouche M, Goodman SB. The biological response to orthopaedic implants for joint replacement: Part I: Metals. Journal of Biomedical Materials Research. Part B, Applied Biomaterials 2016.

Gibon E, Loi F, Córdova LA, Pajarinen J, Lin T, Lu L, Nabeshima A, Yao Z, Goodman SB. Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing. Regenerative Engineering and Translational Medicine 2016;2-2:98-104.

Lin T-H, Pajarinen J, Sato T, Loi F, Fan C, Córdova LA, Nabeshima A, Gibon E, Zhang R, Yao Z, Goodman SB. NF-?B Decoy Oligodeoxynucleotide Mitigates Wear Particle-Associated Bone Loss in the Murine Continuous Infusion Model. Acta Biomaterialia 2016; 41:273-81

Boulezaz S, Gibon E, Loriaut P, Casabianca L, Rousseau R, Dallaudiere B, Pascal-Moussellard H. Spontaneous Knee Ankylosis through Heterotopic Ossification after Total Knee Arthroplasty. Case Reports in Orthopedics 2016;2016:3548512.

Lin T-H, Gibon E, Loi F, Pajarinen J, Córdova LA, Nabeshima A, Lu L, Yao Z, Goodman SB. Decreased osteogenesis in mesenchymal stem cells derived from the aged mouse is associated with enhanced NF-?B activity. Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society 2016.

Gibon E, Córdova LA, Lu L, Lin T-H, Yao Z, Hamadouche M, Goodman SB. The biological response to orthopedic implants for joint replacement. II: Polyethylene, ceramics, PMMA, and the foreign body reaction. Journal of Biomedical Materials Research. Part B, Applied Biomaterials 2016.

Gibon E, Lu L, Goodman SB. Aging, inflammation, stem cells, and bone healing. Stem Cell Research & Therapy. 2016; 7 (1):44

Gibon E, Romana C, Vialle R, Fitoussi F. Isolated C5-C6 avulsion in obstetric brachial plexus palsy treated by ipsilateral C7 neurotization to the upper trunk: outcomes at a mean follow-up of 9 years. The Journal of Hand Surgery, European Volume. 2016;41(2):185-90

Gibon E, Beranger J-S, Bachy M, Delpont M, Kabbaj R, Vialle R. Influence of the bending of the tip of elastic stable intramedullary nails on removal and associated complications in pediatric both bone forearm fractures: A pilot study. International Journal of Surgery (London, England). 2015;16:19-22

Gibon E, Farman T, Marmor S. Knee arthroplasty and lawsuits: the experience in France. Knee surgery, sports traumatology, arthroscopy: official journal of the ESSKA. 2015;23(12):3723-8

Gibon E, Mouton A, Passeron D, Le Strat V, Graff W, Marmor S. Doctor, what does my knee arthroplasty weigh? The Journal of arthroplasty 2014;29(11):2091-4

Goodman SB, Gibon E, Pajarinen J, Lin TH, Keeney M, Ren PG, Nich C, Yao Z, Egashira K, Yang F, Konttinen YT. Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement. Journal of the Royal Society, Interface / the Royal Society 2014;11-93:20130962

Ferre R, Gibon E, Hamadouche M, Feydy A, Drapé J-L. Evaluation of a method for the assessment of anterior acetabular coverage and hip joint space width. Skeletal radiology 2014;43-5:599-605

Gibon E, El Hajj F, Ouaknine M. Arthroscopic Transfer of the Pectoralis Major for Irreparable Tear of the Subscapularis: A Preliminary Report. Arthroscopy Techniques 2014;3-1:e61-e64

Romana C, Gibon E, Vialle R. Total ipsilateral C7 root neurotization to the upper trunk for isolated C5-C6 avulsion in obstetrical brachial plexus palsy: a preliminary technical report. Child’s nervous system: ChNS: official journal of the International Society for Pediatric Neurosurgery 2014;30-5:931-935

Gibon E, Barut N, Anract P, Courpied J-P, Hamadouche M. Ninety-Day Morbidity in Patients Undergoing Primary TKA With Discontinuation of Warfarin and Bridging With LMWH. The Journal of arthroplasty 2014;29(6):1185-8

Zwingenberger S, Yao Z, Jacobi A, Vater C, Valladares RD, Li C, Nich C, Rao A, Christman JE, Antonios JK, Gibon E, Schambach A, Maetzig T, Goodman SB, Stiehler M. Enhancement of BMP-2 induced bone regeneration by SDF-1?± mediated stem cell recruitment. Tissue Engineering. Part A 2014;20-(3-4):810-818.

Valladares RD, Nich C, Zwingenberger S, Li C, Swank KR, Gibon E, Rao AJ, Yao Z, Goodman SB. Toll-like receptors-2 and 4 are overexpressed in an experimental model of particle-induced osteolysis. Journal of biomedical materials research. Part A 2014;102(9):3004-11

Gibon E, Scemama C, David B, Hamadouche M. Oxinium femoral head damage generated by a metallic foreign body within the polyethylene cup following recurrent dislocation episodes. Orthopaedics & traumatology, surgery & research: OTSR 2013;99-7-:865-9.

Zwingenberger S, Yao Z, Jacobi A, Vater C, D Valladares R, Li C, Nich C, Rao AJ, Christman JE, Antonios JK, Gibon E, Schambach A, Matzig T, Gunther K-P, Goodman SB, Stiehler M. Stem cell attraction via SDF-1?± expressing fat tissue grafts. Journal of biomedical materials research. Part A 2013;101-7:2067-2074.

Gibon E, Lagrave B, Rao AJ, Matsoukis J. An Unexpected Foreign Body in the Knee. A Case Report. The Journal of Bone & Joint Surgery Case Connector 2013;3-2:e54 51-55.

Goodman SB, Gibon E, Yao Z. The basic science of periprosthetic osteolysis. Instructional course lectures 2013;62:201-6.

Gibon E, Courpied J-P, Hamadouche M. Total joint replacement and blood loss: what is the best equation? International orthopaedics 2013;37-4:735-9.

Rao AJ, Nich C, Dhulipala LS, Gibon E, Valladares R, Zwingenberger S, Smith RL, Goodman SB. Local effect of IL-4 delivery on polyethylene particle induced osteolysis in the murine calvarium. Journal of biomedical materials research. Part A 2013;101-7:1926-1934.

Fritton K, Ren P-G, Gibon E, Rao AJ, Ma T, Biswal S, Gambhir SS, Goodman SB. Exogenous MC3T3 preosteoblasts migrate systemically and mitigate the adverse effects of wear particles. Tissue Engineering. Part A 2012;18-23-24:2559-67.

Gibon E, Yao Z, Rao AJ, Zwingenberger S, Batke B, Valladares R, Smith RL, Biswal S, Gambhir SS, Goodman SB. Effect of a CCR1 receptor antagonist on systemic trafficking of MSCs and polyethylene particle-associated bone loss. Biomaterials 2012;33-14:3632-8.

Gibon E, Batke B, Jawad MU, Fritton K, Rao A, Yao Z, Biswal S, Gambhir SS, Goodman SB. MC3T3-E1 osteoprogenitor cells systemically migrate to a bone defect and enhance bone healing. Tissue Engineering. Part A 2012;18-9-10:968-73.

Gibon E, Ma T, Ren P-G, Fritton K, Biswal S, Yao Z, Smith L, Goodman SB. Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles. Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society 2012;30-4:547-53.

Rao AJ, Gibon E, Ma T, Yao Z, Smith RL, Goodman SB. Revision joint replacement, wear particles, and macrophage polarization. Acta Biomaterialia 2012;8-7:2815-23.