Tumor necrosis factor-a (TNF-a) inhibitors are the most widely used first-line biologic therapy for the treatment of rheumatoid arthritis. Much has been written on the concern that TNF-a inhibitors may increase the risk of malignancy, infections, and other serious adverse events.
Fibrosis arises from excessive deposition of extracellular matrix components and results in scarring of various tissues. It is a hallmark of systemic sclerosis (SSc), which is a prototypical fibrotic disease affecting both the skin and many internal organs such as the lungs and gastrointestinal tract.
Evidence of a shared pathogenic basis across connective tissue diseases (CTDs) is provided by familial and individual aggregation of autoimmune diseases and by the well-known pleiotropism of autoimmune susceptibility genes.
Systemic sclerosis (SSc) is a chronic systemic disease with a complex pathogenesis. The disease is characterized by early vascular alterations and activation of the immune system, with autoimmune features preceding the deposition of extracellular matrix, leading to systemic fibrosis.
Skeletal involvement, especially on cortical bone, is a hallmark of primary hyperparathyroidism (PHPT). After successful parathyroidectomy (PTX), increases in bone mineral density (BMD), both in symptomatic and in mild asymptomatic PHPT have been demonstrated.
Osteoporosis (OP) and fractures are major causes of morbidity in subjects with rheumatic inflammatory diseases. The etiology of bone loss in rheumatic diseases is multifactorial, involving age, disability, low body mass index (BMI), longstanding disease, disease-related systemic inflammation, and longterm glucocorticoid (GC) exposure.
Thoracic aortic aneurysms and dissections (TAAD) can occur as inherited mendelian diseases, appearing either as isolated events or associated within a spectrum of clinical features that define various
Regular exercise is encouraged among healthy people to prevent death and disease from cardiovascular disease, osteoporosis, anxiety, and depression. Thus, people with rheumatoid arthritis (RA) who have increased susceptibility for these comorbid conditions may benefit from regular exercise and may be encouraged to exercise.
Rheumatoid arthritis (RA) requires multidisciplinary care and patient empowerment. Patient education is generally recognized as an important component of comprehensive management
programs for RA.
The current trial compared patient education before total hip arthroplasty with the usual verbal information. A randomized, controlled 24-month prospective single-center study was done.
Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic nonbacterial osteomyelitis, is an orphan disease (OMIM#259680) whose prevalence is estimated at 1–2/106 (Orphanet.net) but may well be higher.CRMOwas first described in 1972 by Giedon et al.
Systemic sclerosis (SSc) is characterised by major vascular involvement. Pulmonary arterial hypertension (PAH) is currently an important challenge in SSc and given the severity of this condition and the poor understanding of its risk factors and pathogenesis, there is an urgent need to identify novel risk factors for the development of SSc–PAH.
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of 7 diseases classified by the International League of Associations for Rheumatology (ILAR). Two forms with polyarticular onset were identified: rheumatoid factor (RF)-positive and RF-negative polyarticular JIA (pJIA).
Chronic recurrent multifocal osteomyelitis (CRMO), also known as nonbacterial osteomyelitis (NBO) or chronic non bacterial osteomyelitis (CNO), is an orphan disease (OMIM#259680) and its prevalence is probably underestimated.
Systemic sclerosis (SSc, scleroderma) is a connective tissue disease of unknown etiology that affects particularly the skin. Early stages of SSc are characterized by vascular changes and inflammatory infiltrates in the lesional skin.
Systemic sclerosis (SSc) is an orphan and incurable connective tissue disease characterised by vascular, immune and fibrotic abnormalities in the skin and some internal organs.