23 Sep A very rare cause of acro-osteolysis: Hajdu-Cheney syndrome
Acro-osteolysis refers to destructive lytic changes of the dis-tal phalanges. It usually involves the hands but the feet can alsobe affected.
Publications – Service A
23 Sep All-cause Mortality Associated with TNF-a Inhibitors in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials
Tumor necrosis factor-a (TNF-a) inhibitors are the most widely used first-line biologic therapy for the treatment of rheumatoid arthritis. Much has been written on the concern that TNF-a inhibitors may increase the risk of malignancy, infections, and other serious adverse events.
23 Sep The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor and Contributes to the Development of Experimental Dermal Fibrosis
Fibrosis arises from excessive deposition of extracellular matrix components and results in scarring of various tissues. It is a hallmark of systemic sclerosis (SSc), which is a prototypical fibrotic disease affecting both the skin and many internal organs such as the lungs and gastrointestinal tract.
14 Sep Candidate Gene Study in Systemic Sclerosis Identifies a Rare and Functional Variant of the TNFAIP3 Locus as a Risk Factor for Polyautoimmunity
Evidence of a shared pathogenic basis across connective tissue diseases (CTDs) is provided by familial and individual aggregation of autoimmune diseases and by the well-known pleiotropism of autoimmune susceptibility genes.
14 Sep A Regulatory Variant in CCR6 Is Associated With Susceptibility to Antitopoisomerase-Positive Systemic Sclerosis
Systemic sclerosis (SSc) is a chronic systemic disease with a complex pathogenesis. The disease is characterized by early vascular alterations and activation of the immune system, with autoimmune features preceding the deposition of extracellular matrix, leading to systemic fibrosis.
14 Sep Bone Mineral Density Evolution After Successful Parathyroidectomy in Patients With Normocalcemic Primary Hyperparathyroidism
Skeletal involvement, especially on cortical bone, is a hallmark of primary hyperparathyroidism (PHPT). After successful parathyroidectomy (PTX), increases in bone mineral density (BMD), both in symptomatic and in mild asymptomatic PHPT have been demonstrated.
14 Sep Individual site-specific bone mineral density gain in normocalcemic primary hyperparathyroidism
Normocalcemic primary hyperparathyroidism (PHPT) is characterized by normal serum calcium levels, and the exclusion of causes of secondary hyperparathyroidism.
14 Sep Trabecular Bone Score in Female Patients with Systemic Sclerosis: Comparison with Rheumatoid Arthritis and Influence of Glucocorticoid Exposure
Osteoporosis (OP) and fractures are major causes of morbidity in subjects with rheumatic inflammatory diseases. The etiology of bone loss in rheumatic diseases is multifactorial, involving age, disability, low body mass index (BMI), longstanding disease, disease-related systemic inflammation, and longterm glucocorticoid (GC) exposure.
14 Sep Early-Onset Osteoarthritis, Charcot-Marie-Tooth Like Neuropathy, Autoimmune Features, Multiple Arterial Aneurysms and Dissections: An Unrecognized and Life Threatening Condition
Thoracic aortic aneurysms and dissections (TAAD) can occur as inherited mendelian diseases, appearing either as isolated events or associated within a spectrum of clinical features that define various
syndromes.
14 Sep Influence of Patient Education on Exercise Compliance in Rheumatoid Arthritis: A Prospective 12-month Randomized Controlled Trial
Regular exercise is encouraged among healthy people to prevent death and disease from cardiovascular disease, osteoporosis, anxiety, and depression. Thus, people with rheumatoid arthritis (RA) who have increased susceptibility for these comorbid conditions may benefit from regular exercise and may be encouraged to exercise.
14 Sep Effect of a Collective Educational Program for Patients with Rheumatoid Arthritis: A Prospective 12-month Randomized Controlled Trial
Rheumatoid arthritis (RA) requires multidisciplinary care and patient empowerment. Patient education is generally recognized as an important component of comprehensive management
programs for RA.
14 Sep Positive Effect of Patient – Education for Hip Surgery
The current trial compared patient education before total hip arthroplasty with the usual verbal information. A randomized, controlled 24-month prospective single-center study was done.
14 Sep Chronic recurrent multifocal osteomyelitis
Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic nonbacterial osteomyelitis, is an orphan disease (OMIM#259680) whose prevalence is estimated at 1–2/106 (Orphanet.net) but may well be higher.CRMOwas first described in 1972 by Giedon et al.
14 Sep TGFβ receptor gene variants in systemic sclerosis-related pulmonary arterial hypertension: results from a multicentre EUSTAR study of European Caucasian patients
Systemic sclerosis (SSc) is characterised by major vascular involvement. Pulmonary arterial hypertension (PAH) is currently an important challenge in SSc and given the severity of this condition and the poor understanding of its risk factors and pathogenesis, there is an urgent need to identify novel risk factors for the development of SSc–PAH.
14 Sep Radiological Peripheral Involvement in a Cohort of Patients with Polyarticular Juvenile Idiopathic Arthritis at Adulthood
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of 7 diseases classified by the International League of Associations for Rheumatology (ILAR). Two forms with polyarticular onset were identified: rheumatoid factor (RF)-positive and RF-negative polyarticular JIA (pJIA).
14 Sep Radiological cervical spine involvement in young adults with polyarticular juvenile idiopathic arthritis
JIA includes a heterogeneous group of diseases classified by the ILAR [1]. Among them, two subsets of polyarticular JIA (pJIA) were identified: RF positive and negative.
14 Sep A large national cohort of french patients with chronic recurrent multifocal osteitis
Chronic recurrent multifocal osteomyelitis (CRMO), also known as nonbacterial osteomyelitis (NBO) or chronic non bacterial osteomyelitis (CNO), is an orphan disease (OMIM#259680) and its prevalence is probably underestimated.
14 Sep Anticyclic Citrullinated Peptide Antibodies in Rheumatoid and Nonrheumatoid Rheumatic Disorders: Experience with 1162 Patients
Autoantibodies are useful for determinations of the diagnosis and prognosis of the various types of inflammatory chronic rheumatisms.
14 Sep Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis
Systemic sclerosis (SSc, scleroderma) is a connective tissue disease of unknown etiology that affects particularly the skin. Early stages of SSc are characterized by vascular changes and inflammatory infiltrates in the lesional skin.
14 Sep Joint and tendon involvement predict disease progression in systemic sclerosis: a EUSTAR prospective study
Systemic sclerosis (SSc) is an orphan and incurable connective tissue disease characterised by vascular, immune and fibrotic abnormalities in the skin and some internal organs.
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