Jérôme Avouac Archives - Hôpital Cochin

23 Sep All-cause Mortality Associated with TNF-a Inhibitors in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials

Posted at 17:16h in Jérôme Avouac, Publi-Rhumato-a

[vc_row row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern" css_animation=""][vc_column][vc_column_text] Tumor necrosis factor-a (TNF-a) inhibitors are the most widely used first-line biologic therapy for the treatment of rheumatoid arthritis. Much has been written on the concern that TNF-a inhibitors may increase the risk of malignancy, infections, and other serious...

23 Sep The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor and Contributes to the Development of Experimental Dermal Fibrosis

Posted at 17:07h in Jérôme Avouac, Publi-Rhumato-a

[vc_row row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern" css_animation=""][vc_column][vc_column_text] Fibrosis arises from excessive deposition of extracellular matrix components and results in scarring of various tissues. It is a hallmark of systemic sclerosis (SSc), which is a prototypical fibrotic disease affecting both the skin and many internal organs such...

14 Sep Anticyclic Citrullinated Peptide Antibodies in Rheumatoid and Nonrheumatoid Rheumatic Disorders: Experience with 1162 Patients

Posted at 17:09h in Jérôme Avouac, Publi-Rhumato-a

[vc_row][vc_column][vc_column_text] Autoantibodies are useful for determinations of the diagnosis and prognosis of the various types of inflammatory chronic rheumatisms. [/vc_column_text][vc_separator type="transparent" position="center" thickness="5" width_in_percentages="" up="10" down="10"][vc_column_text] [button size='medium' style='' text='Télécharger la publication' icon='fa-download' icon_color='' link='https://www.cochin-poa.com/wp-content/uploads/2015/09/publication-rhumatologie-A-5.pdf' target='_blank' color='' hover_color='' border_color='' hover_border_color='' background_color='' hover_background_color='' font_style='' font_weight='' text_align='' margin=''] [/vc_column_text][/vc_column][/vc_row]...

14 Sep Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis

Posted at 17:06h in Jérôme Avouac, Publi-Rhumato-a

[vc_row][vc_column][vc_column_text] Systemic sclerosis (SSc, scleroderma) is a connective tissue disease of unknown etiology that affects particularly the skin. Early stages of SSc are characterized by vascular changes and inflammatory infiltrates in the lesional skin. [/vc_column_text][vc_separator type="transparent" position="center" thickness="5" width_in_percentages="" up="10" down="10"][vc_column_text] [button size='medium' style='' text='Télécharger la publication' icon='fa-download'...

14 Sep Joint and tendon involvement predict disease progression in systemic sclerosis: a EUSTAR prospective study

Posted at 14:51h in Jérôme Avouac, Publi-Rhumato-a

[vc_row][vc_column][vc_column_text] Systemic sclerosis (SSc) is an orphan and incurable connective tissue disease characterised by vascular, immune and fibrotic abnormalities in the skin and some internal organs. [/vc_column_text][vc_separator type="transparent" position="center" thickness="5" width_in_percentages="" up="10" down="10"][vc_column_text] [button size='medium' style='' text='Télécharger la publication' icon='fa-download' icon_color='' link='https://www.cochin-poa.com/wp-content/uploads/2015/09/publication-rhumatologie-A-3.pdf' target='_blank' color='' hover_color='' border_color='' hover_border_color='' background_color=''...

14 Sep Inflammation and Disease Activity are Associated with High Circulating Cardiac Markers in Rheumatoid Arthritis Independently of Traditional Cardiovascular Risk Factors

Posted at 14:49h in Jérôme Avouac, Publi-Rhumato-a

[vc_row][vc_column][vc_column_text] Cardiovascular (CV) disease is now recognized as a major cause of morbidity and mortality in patients with rheumatoid arthritis (RA). Identifying patients with RA at a preclinical stage and/or at high risk of myocardial involvement is crucial because it may allow for the development of preventive...