Candidate Gene Study in Systemic Sclerosis Identifies a Rare and Functional Variant of the TNFAIP3 Locus as a Risk Factor for Polyautoimmunity

Candidate Gene Study in Systemic Sclerosis Identifies a Rare and Functional Variant of the TNFAIP3 Locus as a Risk Factor for Polyautoimmunity

Evidence of a shared pathogenic basis across connective tissue diseases (CTDs) is provided by familial and individual aggregation of autoimmune diseases and by the well-known pleiotropism of autoimmune susceptibility genes.