All-cause Mortality Associated with TNF-a Inhibitors in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials

All-cause Mortality Associated with TNF-a Inhibitors in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials

Tumor necrosis factor-a (TNF-a) inhibitors are the most widely used first-line biologic therapy for the treatment of rheumatoid arthritis. Much has been written on the concern that TNF-a inhibitors may increase the risk of  malignancy, infections, and other serious adverse events.